Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes.

How do you reduce cardiotoxicity of doxorubicin?

Use of PEGylated liposomal doxorubicin has been shown to decrease the cardiotoxicity of this anthracycline, even at doses >500 mg/m2 [64, 65]. The antioxidant, probucol, has been shown to prevent the decrease in LVEF in animal models of doxorubicin cardiotoxicity [66, 67].

What does doxorubicin do to the heart?

Doxorubicin May Cause Heart Damage While other anthracyclines (like epirubicin and mitoxantrone) may also cause heart damage, the chances are more common with doxorubicin. Doxorubicin causes both early and late heart damage (also called cardiotoxicity).

What is the primary toxicity of doxorubicin?

The acute cardiac toxicity of doxorubicin occurs within days of the drug’s administration and occurs in approximately 11% of patients who receive the drug. Acute cardiac toxicity manifests as reversible myopericarditis, left ventricular dysfunction, or arrhythmias.

What type of cardiomyopathy is caused by doxorubicin?

Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown.

Does doxorubicin cause tachycardia?

The incidence of acute cardiotoxicity is approximately 11% [3,4]. The manifestations are usually chest pain due to myopericarditis and/or palpitations due to sinus tachycardia, paroxysmal nonsustained supraventricular tachycardia and premature atrial and ventricular beats.

How does Adriamycin affect the heart?

Cardiotoxicity means permanent damage to the muscles of the heart or the functioning of the heart. Cardiotoxicity can be severe with Adriamycin treatment and may develop late during therapy, or within two to three months after the treatment has ended.

How does doxorubicin act as anticancer?

Mechanisms of anticancer pharmacodynamics There are two proposed mechanisms by which doxorubicin acts in the cancer cell (i) intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair and (ii) generation of free radicals and their damage to cellular membranes, DNA and proteins (shown in Fig. 1) [9].

What is the target of doxorubicin?

Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow. You might have doxorubicin in combination with other chemotherapy drugs.

How does Adriamycin cause heart failure?

Is doxorubicin cardiotoxicity reversible?

Because severe doxorubicin cardiotoxicity is reversible in some patients, aggressive supportive therapy is warranted.

Is doxorubicin an anticancer drug?

Doxorubicin (DOX) is a highly effective anticancer drug with a broad spectrum of activity. Unfortunately, its use is associated with the development of dose-dependent, cumulative, irreversible, and long-lasting cardiotoxic side effects.